HYPERGLYCEMIA INDUCES KEY GENETIC AND PHENOTYPIC CHANGES IN HUMAN LIVER EPITHELIAL HEPG2 CELLS WHICH PARALLEL THE LEPRDB/J MOUSE MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD).

Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern.With a propensity to progress towards non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma, NAFLD is an important link amongst a multitude of comorbidities including obesity, diabetes, and cardiovascular and kidney disease.As several in vivo models

ABSTRACT The arginine catabolic mobile element (ACME) is the largest genomic region distinguishing epidemic USA300 strains of methicillin-resistant Staphylococcus aureus (MRSA) from other S.aureus strains.However, the functional relevance of ACME to infection and disease has remained unclear.Using phylogenetic analysis, we have shown that the modul

The established role of the male partner in overall infertility is almost 50%.1 The most significant cause is degraded number as well as the quality of sperms.2 Spermatogenesis is governed by gonadotropin-releasing hormone (GnRH) then follicle-stimulating hormone (FSH) and finally by testosterone, which is linked with puberty, and essentially requi